Understanding Low Dose Naltrexone (LDN)

Written by: Dr Tim Trodd (Functional Medicine)

Low Dose Naltrexone ( LDN) is a readily available and inexpensive anti-inflammatory. One major benefit is that unlike other anti-inflammatories it does not cause gastrointestinal problems, this make it particularly useful for use in children with inflammatory conditions such as PANS / PANDAS.

What is Low Dose Naltrexone?

Low Dose Naltrexone refers to the administration of naltrexone in much smaller doses than what is previously used. While the standard dose for addiction treatment usually ranges from 50 to 100 mg, low doses range from 0.5 to 4.5 mg per day. This low dosage regimen modulates the immune system and reduces inflammation.

How Does LDN Work?

The mechanism by which LDN works is not entirely understood, but it is believed to involve the temporary blocking of opioid receptors in the body. This blockage prompts the body to increase the production of endorphins and enkephalins, which are natural painkillers and immune modulators. The increased levels of these substances helps to regulate the immune system, reduce inflammation, and alleviate pain.

Conditions Treated by Low Dose Naltrexone

Autoimmune Diseases

LDN has shown promise in treating a variety of autoimmune diseases by helping to regulate an overactive immune response. Conditions such as multiple sclerosis, Crohn's disease, rheumatoid arthritis, and lupus may benefit from LDN therapy.

Chronic Pain

Chronic pain conditions, including fibromyalgia and complex regional pain syndrome, may be alleviated by LDN. Its pain-relieving effects are thought to result from the modulation of inflammatory pathways and increased production of natural endorphins.

Inflammatory Conditions

Given its anti-inflammatory properties, LDN is also being explored for use in conditions characterized by chronic inflammation, such as inflammatory bowel disease (IBD) and Long Covid.

Cancer

Some early research suggests that LDN might have a role in cancer treatment, particularly in reducing tumour growth and managing symptoms. However, more extensive clinical trials are needed to fully understand its potential in oncology.

Neurodegenerative Diseases

LDN has been studied for its potential benefits in neurodegenerative conditions like Parkinson's disease and Alzheimer's disease, where inflammation and immune dysregulation are contributing factors.

Other Conditions

Beyond the above, LDN is being researched for a variety of other health issues, including depression and anxiety. It is also useful for treating children with conditions such as Autism and PANS / PANDAS when inflammation is a part of the disease process

Conclusion

Low Dose Naltrexone is an emerging treatment that holds promise for a wide range of conditions, particularly those involving chronic pain, inflammation, and immune dysregulation. Always consult with a healthcare professional before starting any new treatment regimen.