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LEQVIO (Inclisiran)

LEQVIO works by silencing a specific gene in the liver, improving the regulation of the Low-density lipoproteins (LDLs), or the bad cholesterol.

Last Modified: 21 May 2024

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LEQVIO, with the generic name inclisiran, is a novel cholesterol-lowering medication. Unlike traditional statins, LEQVIO works by silencing a specific gene in the liver, improving the regulation of the Low-density lipoproteins (LDLs), or the bad cholesterol. 

Contents and Ingredients 

  • Active Ingredient: Inclisiran 

Chemical Structure and Manufacture 

LEQVIO is a small interfering RNA (siRNA) therapy, synthesised through advanced biotechnological processes targeting the PCSK9 gene, which plays a crucial role in regulating cholesterol. 

Global Name

  • Generic Name: Inclisiran
  • Brand Name: LEQVIO 


What is LEQVIO used for?

LEQVIO is used to treat: 

  • Hypercholesterolemia (elevated cholesterol levels) 
  • Heterozygous familial hypercholesterolemia (genetically related) 
  • Mixed Dyslipidemia 
    It serves as an adjunct to diet and maximally tolerated statin therapy. 

How do you use LEQVIO? 

Dosage Information 

  • Administered as a subcutaneous injection. 
  • Initial doses at Day 1 and Day 90, followed by a maintenance dose every 6 months. 


  • Suitable for adults with clinical atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. 
  • Not recommended for children or adolescents. 


  • Individuals with active liver disease or severe renal impairment. 
  • Pregnancy and breastfeeding women. 

Allergy Information 

  • Patients with a known allergy to Inclisiran or excipients in LEQVIO. 

Warnings and Precautions 

  • Monitor liver enzymes and renal function. 
  • No food restrictions related to the timing of the injection. 

Interactions and Contraindications 

  • Unknown interactions with other lipid-lowering therapies. 
  • Avoid in patients with a history of a life-threatening reaction to similar drugs. 

Side Effects

Common side effects may include injection site reactions, joint pain, urinary tract infections, diarrhoea, and chest pain. 

Note: Always report concerning side effects to your healthcare provider. 

Pharmacist Tips

Storage Information 

  • Store at room temperature. 
  • Protect from light. 

Handling Instructions 

  • Allow LEQVIO to reach room temperature before administration. 
  • Do not shake the vial. 


Where is LEQVIO available in Hong Kong?

Availability in Hong Kong

LEQVIO is a prescription medication that can be prescribed by healthcare providers.


How often is LEQVIO administered? 

After the initial two doses, LEQVIO is given once every six months. 

Can LEQVIO replace statins?

LEQVIO is used in conjunction with statins, not as a replacement.

Is LEQVIO a pill?

No, LEQVIO is an injectable medication.

Does LEQVIO interact with other medications?

There are no known significant interactions, but always consult your healthcare provider.

What happens if I miss a dose?

Depends on the next planned dose schedule. If a planned dose is missed by more than 3 months, consult your healthcare provider as you may need to restart with a new dosing schedule.  


This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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