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Pantoprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach.

Last Modified: 28 Jun 2024

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What is Pantoprazole? 

Pantoprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is commonly used to treat gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. 

The active ingredient in Pantoprazole is pantoprazole sodium, which inhibits the sodium-potassium (proton) pump in the stomach lining, a crucial step in acid production. 

Global Name

The generic name of Pantoprazole is pantoprazole sodium, and it is available under several brand names, including Protonix and Pantoloc. 


What is Pantoprazole used for? 

Pantoprazole is used to treat a variety of conditions related to the stomach and esophagus, including: 
  • Gastroesophageal reflux disease (GERD) 
  • Erosive esophagitis (damage to the esophagus from stomach acid) 
  • Zollinger-Ellison syndrome (a condition where the stomach produces too much acid) 
  • Other conditions involving excessive stomach acid, e.g. NSAID-induced gastritis, H. pylori-associated gastritis 

How do you use Pantoprazole?  


Pantoprazole is available in tablet form and as an injectable solution.

Dosage information:

  • Adults: Typically, 40 mg once daily for 4 to 8 weeks for GERD. For Zollinger-Ellison syndrome, the dose can be adjusted according to medical advice; for H. pylori eradication: as part of quadruple therapy together with bismuth, metronidazole and tetracycline for 10-14 days. 
  • Children: Usage and dose should be determined by a pediatrician. 


  • Children: Yes, however it must be prescribed by a healthcare provider
  • Adults: Yes. 
  • Elderlies: Yes, no dosage adjustment is generally required. 
  • Pregnancy: Should be used only if clearly needed and directed by a healthcare provider. 
  • Lactation: Consult with a doctor before use. 

Is there anyone who can’t take Pantoprazole? 

  • Adults: Not recommended for those with severe liver impairment. 

Allergies: Those allergic to pantoprazole or any other proton pump inhibitor should avoid this medication. 


Warnings and Precautions:

  • Long-term use may increase the risk of bone fractures, especially in the hip, wrist, or spine. 
  • May interfere with vitamin B12, vitamin C, calcium, iron and magnesium absorption. Monitor these micronutrient levels especially for prolonged and recurrent treatment periods. 
  • May increase risk of Clostridium difficile infection in long-term users. 

Drug and Food/Beverage Interactions

  • Pantoprazole may interact with drugs such as methotrexate and warfarin. 
  • Not recommended for use with HIV medications and certain antifungal drugs without medical supervision. 

Side Effects

Common side effects include headache, diarrhea, nausea, and abdominal pain. Serious side effects may include kidney damage, bone fractures, and Clostridium difficile-associated diarrhea. 

Pharmacist Tips

Storage information: 
Store at room temperature away from moisture, heat, and light. 

Handling instructions: 
Do not crush, chew, or split the tablets. Swallow them whole. 


Where is Pantoprazole available in Hong Kong?

Pantoprazole is a prescription medication that can be prescribed by healthcare providers.



How long does it take for Pantoprazole to work?

Symptoms usually improve within a few days of starting the medication, but it may take up to four weeks for full effect.

Can Pantoprazole be taken long-term? 

Long-term use should be managed and monitored by a healthcare provider due to potential side effects.

Does Pantoprazole interact with other medications?

Yes, it can interact with certain medications, so it’s important to discuss all current medications with a healthcare provider.

Can I stop taking Pantoprazole abruptly? 

It is not recommended to stop Pantoprazole abruptly without consulting a healthcare provider as it may cause rebound acid secretion and treatment failure.

This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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