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Holopon is a medicinal drug primarily used to treat various gastrointestinal disorders.

Last Modified: 04 Jul 2024

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What is Holopon?  

Holopon is a medicinal drug primarily used to treat various gastrointestinal disorders. Its active ingredient, hyoscine methylbromide (also known as scopolamine butylbromide, methoscopolamine bromide), is effective in relieving cramps and spasms in the stomach, intestines, and bladder by relaxing the smooth muscles in these organs. 

Hyoscine methylbromide works as an antispasmodic agent, blocking the action of acetylcholine in nerve endings, which reduces muscle spasms and the associated pain. 

Global Name

The generic name for Holopon is hyoscine methylbromide, and it is currently the only brand name of the drug being sold.


What is Holopon used for? 

Holopon is used to alleviate symptoms associated with: 

How do you use Holopon?  


Holopon is available in tablet form.

Dosage information:

  • Adults: 10-20 mg up to four divided doses a day. 
  • Children (over 6 years):  Safety and efficacy in children have not been established. Recommend alternative medications.
  • Elderlies: Dose adjustment may be necessary due to sensitivity to antimuscarinic effects. 

Are the following suitable to take the drug: Children, adults, elderlies? 

  • Children: Safety and efficacy in children have not been established. Recommend alternative medications. 
  • Adults: Suitable. 
  • Elderlies: Suitable, with dose adjustments as necessary.
Is there anyone who can’t take Holopon? 
  • Children: Not recommended for children.  
  • Adults: Those with myasthenia gravis, megacolon, glaucoma, urinary retention, and severe ulcerative colitis should avoid it. 
  • Elderlies: Caution is advised due to increased sensitivity to antimuscarinics. 
  • Pregnancy: Should be used only if clearly needed and directed by a healthcare provider. Pregnancy category C. 
  • Lactation: Caution advised as it's unknown if hyoscine methylbromide passes into breast milk. Recommend alternative medications. 

Allergies: Individuals allergic to hyoscine methylbromide or any components of the drug or similar anticholinergic alkaloids like hyoscine butylbromide (e.g. Buscopan) should not use Holopon. 


Warnings and Precautions:

  • Caution is advised in patients with glaucoma, enlarged prostate, or any condition where anticholinergic effects might worsen symptoms. 
  • Holopon should be taken before meals if taken orally to enhance effectiveness in reducing cramps and discomfort. 

Drug and Food/Beverage Interactions

Avoid using Holopon with other anticholinergic drugs as it may increase side effects. It is contraindicated in patients with myasthenia gravis, megacolon, urinary retention and severe ulcerative colitis. 

Side Effects

Common side effects include dry mouth, dizziness, blurred vision, and urinary retention. Severe side effects may include anaphylaxis, angioedema, and increased heart rate.

Pharmacist Tips

Storage information:

Store at room temperature away from moisture and heat. 
Handling instructions:

Keep the tablets in their original package to protect from light.



Where is Holopon available in Hong Kong?

Holopon is a prescription medication that can be prescribed by healthcare providers.



Can Holopon be used for nausea? 

No, Holopon is not typically used for nausea as its primary function is to relieve muscle spasms in the gastrointestinal tract. 

How quickly does Holopon work?

Holopon typically begins to work within 30 minutes when taken orally, and faster if administered via injection. 

Can I drive after taking Holopon? 

Caution is advised as Holopon can cause dizziness and blurred vision; it's best to know how it affects you before driving or operating machinery. 

Is Holopon suitable for pregnant women? 

Holopon should only be used in pregnancy if clearly needed and under the advice of a healthcare provider due to the lack of extensive safety data. Pregnancy category C. 

This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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