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Febuxostat

Febuxostat is a xanthine oxidase inhibitor used to lower uric acid levels in the blood.

Last Modified: 28 Mar 2024

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Overview

What is Febuxostat? 

Febuxostat is a xanthine oxidase inhibitor used to lower uric acid levels in the blood. 

Febuxostat is synthesized through a complex chemical process to inhibit the enzyme xanthine oxidase, responsible for uric acid production. 

Global Name

Generic name: Febuxostat 
Brand names: Uloric, Adenuric, Feburic 


Usage

What is Febuxostat used for? 

Febuxostat is primarily used for the chronic (long-term/maintenance) management of hyperuricemia in patients with gout. 


How do you use Febuxostat? 

Availability:

Febuxostat is available in tablet form. 

Dosage information: 

  • Adults: The typical starting dose is 40 mg once daily, which may be increased to 80 mg if uric acid levels remain high. 
  • Children: Not typically recommended for children. 

Suitability: 

  • Children: Febuxostat is generally not recommended for use in children. 
  • Adults: Suitable for adult patients. 
  • Elderlies: Can be used in elderly patients; however, dose adjustment may be necessary based on renal function.
  • Allergies: Patients with a known hypersensitivity to Febuxostat or its components should not use this medication. 

Is there anyone who can’t take Febuxostat? 

  • Children: The safety and effectiveness of Febuxostat in pediatric patients have not been established. 
  • Adults: Adults with severe renal or hepatic impairment should avoid Febuxostat. 
  • Elderlies: No absolute contraindication, but caution is advised. 
  • Pregnancy and Lactation: Febuxostat should only be used if the potential benefit justifies the potential risk to the fetus. Please consult with a medical professional. 

Any warnings and precautions : 

Febuxostat may increase the risk of cardiovascular events. Patients with a history of heart disease should use it with caution. 

Interactions: 
Febuxostat may interact with azathioprine, mercaptopurine, and theophylline. It should not be used by patients on these medications without a doctor’s supervision. 

Side Effects

Common side effects include liver enzyme abnormalities, nausea, joint pain, and rash. Serious side effects can include heart-related events and severe allergic reactions. 

Pharmacist Tips

  • Regular Testing: While on Febuxostat, regular blood tests to monitor your uric acid levels and liver function are crucial. 
  • Fluid Intake: Increase your fluid intake to help reduce uric acid concentrations and prevent kidney stones. 
  • Dietary Considerations: Maintain a balanced diet low in purines, which can contribute to uric acid buildup. 
  • Gout Flare Prophylaxis: Your doctor may prescribe an additional medication to prevent gout flares when you start taking Febuxostat. 
  • Adherence to Therapy: Do not stop taking Febuxostat without consulting your healthcare provider, as abruptly stopping can lead to gout flares. 
  • Storage Information: Store Febuxostat at room temperature, away from moisture and heat. 
  • Handling Instructions: Handle with clean, dry hands and consume immediately after removing from the packaging. 

Availability

Where is Febuxostat available in Hong Kong?

Febuxostat  is a prescription medication that can be prescribed by healthcare providers and bought in pharmacies. 

FAQs

Can I take Febuxostat during a gout attack?

Febuxostat is not meant for acute gout attacks but for long-term management of uric acid levels. 

How long does it take for Febuxostat to work? 

Febuxostat can start reducing uric acid levels within two weeks, but it may take several months to achieve the full effect. 

Is Febuxostat available for purchase over the counter?

No, Febuxostat requires a doctor's prescription. 

When to stop Febuxostat?

The decision to stop taking febuxostat should be made in consultation with a healthcare professional, such as a doctor or rheumatologist, who can assess your specific medical condition and treatment needs.   

Disclaimer
This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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