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Clotrimazole is an antifungal medication widely used to treat fungal skin infections.

Last Modified: 21 May 2024

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What is Clotrimazole? 

Clotrimazole is an antifungal medication widely used to treat fungal skin infections. It belongs to a class of drugs known as azole antifungals and works by disrupting the cell membrane of fungi, inhibiting their growth and replication. 

Clotrimazole is a synthetic compound, produced through chemical synthesis, involving the creation of a dichlorophenyl ring, which is essential for its antifungal properties. 

Global Name

Generic Names: Clotrimazole

Global Brand Names:  Lotrimin, Gyne-Lotrimin, Canesten, Mycelex 


What is Clotrimazole used for? 

Clotrimazole is used to treat various fungal infections, including: 

  • Athlete's foot (tinea pedis) 
  • Jock itch (tinea cruris) 
  • Ringworm (tinea corporis) 
  • Oral thrush (candidiasis) 
  • Vaginal yeast infections (vulvovaginal candidiasis) 
  • Fungal nail infections (onychomycosis) 

How do you use Clotrimazole? 


Clotrimazole is available in several forms, including creams, lotions, powders, troches (lozenges), and pessary (vaginal tablet). 

Dosage information: 

  • Athlete's foot, jock itch, and ringworm: Apply a thin layer to the affected area 2-3 times a day for 2-4 weeks. 
  • Vaginal yeast infections: Use a single application of the vaginal cream or vaginal tablet, typically at bedtime for 1-7 days depending on the product strength. 
  • Oral thrush: Use one lozenge five times daily for 14 consecutive days.
  • Children: Can be used in children for skin infections, but dosage and duration should be determined by a pediatrician. 
  • Adults: Suitable for all adult age groups. 
  • Elderlies: No dosage adjustment is generally necessary.


  • Children: Safe for children under medical supervision. 
  • Adults: Generally safe, unless allergic to the medication. 
  • Elderlies: Can be used with no specific contraindications. 
  • Pregnancy and Lactation: Clotrimazole should only be used during pregnancy if clearly needed. Caution should be exercised when used by nursing mothers. 
  • Allergies: Patients with a known hypersensitivity to Clotrimazole or any of its ingredients should not use this medication. 

Any warnings and precautions : 
Avoid contact with the eyes, mouth, or nose when using topical forms of Clotrimazole. If your infection does not improve within the recommended time frame, or if it worsens, seek medical attention. 

Clotrimazole is generally considered safe with minimal drug interactions. However, it is always best to inform your healthcare provider about all medications you are taking. 

Side Effects

Possible side effects include local irritation, itching, or redness at the application site. Severe allergic reactions to Clotrimazole are rare. 

Pharmacist Tips

As a pharmacist, it is important to provide comprehensive guidance to ensure the safe and effective use of Clotrimazole. Here are some additional tips: 

  • Appropriate Use: Clotrimazole should be used exactly as directed. Overuse or improper application can lead to decreased effectiveness or increased risk of side effects. 
  • Avoid occlusive dressings: Unless directed by a healthcare provider, do not cover the treated area with airtight dressings such as bandages. This can increase the risk of side effects. 
  • Cross-contamination: Avoid sharing personal items like towels or clothing that may have come into contact with the fungus to prevent spreading the infection to others. 
  • Completing the course: It is crucial to complete the full course of treatment, even if the symptoms appear to resolve before finishing the medication. This reduces the risk of recurrence. 
  • Monitoring Progress: If there is no improvement after the recommended treatment duration, consult a healthcare professional. The infection might require alternative treatment. 
  • Avoiding other products: Do not use other topical products on the affected area unless advised by a healthcare provider, as they may affect how Clotrimazole works or increase irritation. 
  • Use in intimate areas: If using Clotrimazole for vaginal yeast infections, understand that it can weaken latex condoms and diaphragms, reducing their effectiveness as birth control methods. 
  • Alcohol-based solutions: Some formulations of Clotrimazole are alcohol-based and should not be applied to irritated skin or near an open flame. 
  • Sun exposure: The affected skin can become more sensitive. Avoid extensive sun exposure, tanning booths, and sunlamps. 
  • Vaginal use: If using the vaginal cream or tablets, lying down as soon as possible after inserting them can help the medicine stay in place and avoid leakage. 
  • Reporting side effects: If you experience any side effects, particularly if they are severe or persistent, report them to your healthcare provider. 
  • Informing your healthcare provider: Always inform your healthcare provider of all the products you are using, as there may be interactions with other prescribed or over-the-counter medications. 


Where is Clotrimazole available in Hong Kong?

Clotrimazole is an over the counter (OTC) medication that can be sold without a prescription. It is found in all chain drug stores, including Mannings and Watsons in Hong Kong. 


Can Clotrimazole be used for diaper rash?

Clotrimazole can be used for diaper rash if it is fungal-related, such as a yeast infection. Consult a healthcare provider for proper diagnosis and treatment. 

How long does it take for Clotrimazole to work?

Improvement in symptoms can often be seen within a few days, but it may take up to two weeks for a skin infection to heal completely. 

Is Clotrimazole available for purchase over the counter? 

Yes, Clotrimazole is available for purchase over the counter for the treatment of skin infections, while the vaginal cream and some formulations may require a prescription. 


This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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