Rosuvastatin

Overview

What is Rosuvastatin?   

Rosuvastatin is a cholesterol-lowering medication that belongs to a group of drugs known as statins. It works by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the liver. The reduction in cholesterol levels can help decrease the risk of cardiovascular disease, including heart attacks and strokes. 

Global Name

• Generic name:  Rosuvastatin
• Brand names: Crestor, Rosulip, and Rostar

Usage

What is Rosuvastatin used for? 

Rosuvastatin is used to treat several conditions, primarily: 

• Lowering "bad" cholesterol (LDL) and triglycerides levels in the blood. 

• Increasing "good" cholesterol (HDL) levels. 

• Reducing the risk of heart attacks and strokes. 

• Managing hypercholesterolemia and mixed dyslipidemia. 

How do you use Rosuvastatin? 

Availability: 

Rosuvastatin is available in tablet form.

Dosage information: 

• Adults: The usual starting dose is 5-10 mg once daily. 

• Children (aged 8 years and above): The starting dose is 5 mg once daily. 

• Elderlies: Dose adjustment may not be necessary, but caution is advised due to potential for increased sensitivity. 

Are the following suitable to take the drug: Children, adults, elderlies? 

• Children: Suitable for children 8 years and older. 

• Adults: Suitable. 

• Elderlies: Suitable, with caution.

Is there anyone who can’t take Rosuvastatin? 

• Children: Not recommended for children under 8 years. 

• Adults: Not suitable for those with liver disease or those who consume excessive amounts of alcohol. 

• Elderlies: Use with caution; monitor liver and muscle function regularly. 

• Pregnancy: Contraindicated due to the risk of harm to the fetus. 

• Lactation: Not recommended as it can pass into breast milk. 

Allergies: Individuals allergic to rosuvastatin or any component of the formulation should avoid this medication. 

Warnings and precautions: Patients should be advised to promptly report muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Liver function tests should be performed before starting treatment and thereafter when clinically indicated. 

Rosuvastatin should be taken at any time of day, with or without food. 

Interactions and contraindications of the drug: 
Rosuvastatin should not be used in combination with drugs that may increase the risk of myopathy and rhabdomyolysis, such as gemfibrozil and other fibrates, and certain antiviral medications. 

Side Effects

Common side effects include headache, muscle pain, abdominal pain, weakness, and nausea. Serious side effects may include liver damage, muscle problems, and kidney failure. 

Pharmacist Tips

• Storage information: Store at room temperature, away from excess heat and moisture. 

• Handling instructions: Handle the tablets with clean, dry hands and store them in their original packaging until use to protect from moisture. 

Availability

Where is Rosuvastatin available in Hong Kong?

Rosuvastatin is a prescription medication that can be prescribed by healthcare providers.

FAQs

Can Rosuvastatin be taken with food? 

Yes, Rosuvastatin can be taken with or without food. 

What should I do if I miss a dose of Rosuvastatin? 

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. 

Is it safe to consume alcohol while taking Rosuvastatin?  

Excessive alcohol consumption is not recommended as it may increase the risk of liver problems. 

How long does it take for Rosuvastatin to work? 

You may see an improvement in cholesterol levels within 2 to 4 weeks of starting Rosuvastatin.