Prednisolone

Overview

What is Prednisolone?   

Prednisolone (潑尼松龍/腎上腺皮質酮) is a synthetic corticosteroid drug that mimics the effects of the hormone cortisol that is produced naturally in the adrenal glands. It is primarily used to suppress the immune system and reduce inflammation in the body. 

Global Name

• Generic name:  Prednisolone

Usage

What is Prednisolone used for? 

Prednisolone is used to treat a wide range of health issues including: 

• Autoimmune disorders such as lupus and multiple sclerosis 

• Allergic reactions and asthma 

• Certain types of arthritis 

• Skin conditions 

• Some types of cancer 

• Anti-organ rejection in transplant surgery 

How do you use Prednisolone? 

Availability: 
Prednisolone is available in various forms including tablets, soluble tablets, and as an injectable solution. 

Dosage information: 

• Adults: Dosage varies based on the condition being treated but often starts with a higher dose before tapering down. 

• Children: Doses are usually lower and must be determined by a pediatrician based on weight and condition. 

• Elderlies: May require lower doses due to potential side effects affecting the heart, kidneys, and liver. 

Are the following suitable to take the drug: Children, adults, elderlies? 

• Children: Suitable under medical supervision. 

• Adults: Suitable for adults under medical supervision. 

• Elderlies: Suitable, but with caution due to increased risk of side effects. 

Is there anyone who can’t take Prednisolone? 

• Children: Suitable under medical supervision. 

• Adults: Those with systemic fungal infections should not use prednisolone. 

• Elderlies: Use with caution; monitor for side effects. 

• Pregnancy: Should be used only if clearly needed and the potential benefits justify the potential risks to the fetus. 

• Lactation: Caution is advised as it could affect milk production or have effects on the nursing infant. 

Allergies: Individuals who have had allergic reactions to prednisolone or any of its components should avoid this medication. 

Warnings and precautions: Long-term use of prednisolone can lead to potentially serious side effects including osteoporosis, increased risk of infections, obesity, diabetes, Cushing’s syndrome and adrenal suppression. It is important to follow dosing instructions closely and not to discontinue the medication abruptly. 

Interactions and contraindications of the drug: 

 Prednisolone should be used cautiously with nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, and diabetes medications as it may exacerbate or alter their effects. 

Side Effects

Side effects of prednisolone can include skin pigmentation changes, weight gain, swelling, high blood pressure, mood swings, and increased risk of infections. Long-term use can lead to more serious conditions including osteoporosis, obesity, diabetes, Cushing’s syndrome and adrenal suppression. 

Pharmacist Tips

• Storage information: Store at room temperature, away from direct light and moisture. 

• Handling instructions: Handle tablets with clean, dry hands. Follow prescription guidelines for disposal to avoid environmental contamination.

Availability

Where is Prednisolone available in Hong Kong?

Prednisolone is a prescription medication that can be prescribed by healthcare providers. 

FAQs

How long does it take for Prednisolone to work? 

Prednisolone typically begins to work within hours of intake, but the full effect may take a few days.

Can I drink alcohol while taking Prednisolone? 

Alcohol can increase the risk of gastrointestinal problems when taking prednisolone, so it is best avoided. 

How should Prednisolone be discontinued? 

Prednisolone should be tapered off (decreasing dosage) gradually under medical supervision to avoid withdrawal symptoms and adrenal insufficiency.

Does Prednisolone affect mood or behavior?  

Yes, prednisolone can affect mood and may cause mood swings, anxiety, or irritability.