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Pantoloc is a medication that contains pantoprazole, a proton pump inhibitor (PPI) used to reduce the amount of stomach acid produced by the glands in the lining of the stomach.

Last Modified: 06 May 2024

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What is Pantoloc? 

Pantoloc is a medication that contains pantoprazole, a proton pump inhibitor (PPI) used to reduce the amount of stomach acid produced by the glands in the lining of the stomach. It is also prescribed under brand names such as Protonix (USA), Peptazole (Hong Kong), Panzole (Singapore) and comes in tablet form, as well as an injectable solution for hospital use. 

Pantoprazole is synthesised through a complex chemical process that yields its stable, benzimidazole derivative form, which selectively inhibits the H+/K+ ATPase enzyme system—the "proton pump" - in the gastric parietal cells thereby reducing stomach acid production to almost nil. 


Global Name

Generic name:  Pantoprazole
Brand names: Pantoloc, Protonix, Panto IV, Pantocid, Pantopan, Pantozol, Somac, Pantozol, Controloc, Nolpaza, Zurcal 


What is Pantoloc used for? 

Pantoloc is used to treat various conditions related to stomach acid, such as: 

How do you use Pantoloc? 


Pantoloc is available as delayed-release tablets and as an injectable solution.

Dosage information:

  • GERD: 40 mg once daily for up to 8 weeks. 
  • Erosive esophagitis: 40 mg once daily for 4-8 weeks. 
  • Zollinger-Ellison syndrome: 40 mg twice daily, with dosage adjusted as needed. 


  • Children: Not typically recommended; consult a pediatrician. 
  • Adults: Yes, commonly prescribed. 
  • Elderlies: Yes, no adjustment necessary in the absence of renal impairment. 
  • Pregnancy: Should only be used if clearly needed and prescribed by a doctor. 
  • Lactation: Caution advised; a doctor should be consulted. 

Is there anyone who can’t take Pantoloc? 

  • Children: Safety in children has not been established. 
  • Adults: Those with a known hypersensitivity to pantoprazole or other PPIs. 
  • Elderlies: Generally safe, but should be used with caution due to possible multiple drug intake. 
  • Pregnancy: Use only if the potential benefit justifies the potential risk. 
  • Lactation: Consult a healthcare provider before use. 

People with severe liver impairment should also use Pantoloc with caution. The drug should be taken before meals, preferably in the morning, and should not be crushed or chewed. 


Drug Interactions: 

Pantoloc may interact with medications such as clopidogrel, methotrexate, and HIV medications. It should not be used with atazanavir or nelfinavir.

Side Effects

Common side effects can include headache, diarrhea, nausea, and abdominal pain. Serious side effects are rare but can include severe allergic reactions and Clostridium difficile-associated diarrhea. 

Pharmacist Tips

  • Store Pantoloc at room temperature, away from moisture and heat. 
  • Do not stop taking Pantoloc abruptly without consulting your healthcare provider, as this could worsen symptoms. 
  • If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. 


Where is Pantoloc available in Hong Kong?

Pantoloc is a prescription medication that can be prescribed by healthcare providers. 



Can I take Pantoloc on an empty stomach?

Yes, Pantoloc should be taken before eating, preferably in the morning. 

How long does Pantoloc take to work? 

Pantoloc may start reducing stomach acid within an hour, with full effect in about 2 hours.

Can Pantoloc be taken long-term?

Pantoloc is sometimes taken long-term under medical supervision; however, long-term use requires regular medical assessment.

Can I drink alcohol while taking Pantoloc? 

Alcohol can irritate your stomach, and while not directly contraindicated, it's best to avoid alcohol when taking Pantoloc. 

This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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