Omeprazole

Overview

What is Omeprazole?   

Omeprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It’s primarily used to treat certain stomach and esophagus problems such as dyspepsia-hyperacidity, acid reflux and stomach and duodenal ulcers. 

Global Name

• Generic name:  Omeprazole
• Brand name: Prilosec and Losec

Usage

What is Omeprazole used for? 

Omeprazole is used to treat: 

• Gastroesophageal reflux disease (GERD) 

• Erosive esophagitis 

• Zollinger-Ellison syndrome 

• Duodenal and gastric ulcers 

• Heartburn or dyspepsia 

• H. pylori eradication therapy 

How do you use Omeprazole? 

Availability: 
Omeprazole is available primarily in capsule form, but it is also available as tablets, intravenous injectable and as an oral suspension. 

Dosage information: 

• Adults: Typically, 20 mg to 40 mg once daily for 4 to 8 weeks, depending on the condition being treated. 

• Children: The dose for children is based on body weight and the condition being treated and should be determined by a pediatrician. 

• Elderlies: No adjustment of dose is generally required. 

Are the following suitable to take the drug: Children, adults, elderlies? 

• Children: Yes, under medical supervision for specific conditions. 

• Adults: Suitable for adults. 

• Elderlies: Suitable for elderly patients; no dosage adjustment necessary in the absence of significant renal impairment. 

Is there anyone who can’t take Omeprazole? 

• Children: Suitable under medical supervision. 

• Adults: Not recommended for those allergic to omeprazole or other benzimidazole medication like albendazole and mebendazole. 

• Elderlies: Generally safe but should be used with caution. 

• Pregnancy: Generally considered safe but should be used under medical advice. 

• Lactation: Minimal amounts excreted in breast milk; consult with a healthcare provider. 

Allergies: Avoid if allergic to omeprazole or other proton pump inhibitors. 

Warnings and precautions: Long-term use of omeprazole may lead to vitamin B12, iron  and magnesium deficiency. It may also increase the risk of osteoporosis-related fractures in the hip, wrist, or spine. 

Interactions and contraindications of the drug: 

Omeprazole can interact with drugs like clopidogrel, warfarin, and certain antifungals and antibiotics. Care should be taken when used with other medications that may cause magnesium loss. 

Side Effects

Common side effects include headache, stomach pain, nausea, diarrhea, and vomiting. Serious side effects may include kidney problems, lupus, and fractures. 

Pharmacist Tips

• Storage information: Store at room temperature away from moisture and heat. 

• Handling instructions: Handle capsules with clean, dry hands and swallow whole, not crushed or chewed. 

Availability

Where is Omeprazole available in Hong Kong?

Omeprazole is an over-the-counter (OTC) medication that can be sold without a prescription. It is found in all chain drug stores, including Mannings and Watsons. 

FAQs

How long does it take for Omeprazole to work?  

Omeprazole generally starts to reduce stomach acid within one hour of ingestion, with peak effects within one to two days. 

Can I take Omeprazole capsules long-term? 

Long-term use is generally safe under medical supervision, though periodic evaluations are recommended. 

Are there any foods I should avoid while taking Omeprazole? 

No specific foods need to be avoided; however, it's generally advisable to limit foods that exacerbate acid reflux. 

Can Omeprazole be taken on an empty stomach? 

Yes, omeprazole works best when taken on an empty stomach, about 30 minutes before a meal.