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Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used in the management of high blood pressure and heart failure.

Last Modified: 10 May 2024

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What is Lisinopril? 

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used in the management of high blood pressure and heart failure. It works by relaxing blood vessels, allowing blood to flow more easily. 
Lisinopril's structure is that of a lysine-derived peptide, which mimics a component of the enzyme it competitively inhibits. 

Global Name

Generic name: Lisinopril
Brand name: Zestril, Prinivil, and Qbrelis


What is Lisinopril used for? 

Lisinopril is primarily used for treating hypertension (high blood pressure), congestive heart failure, and improving survival after a heart attack. It may also be used in certain cases to prevent kidney problems in patients with diabetes. 

How do you use Lisinopril? 


Lisinopril is available in tablet form.

Dosage information: 

  • Adults: Starting dose is typically 10 mg once daily for hypertension, and 5 mg once daily for heart failure. 
  • Children: Pediatric dosages are determined by a doctor and are based on weight; for ages 6 and above. 


  • Children: Yes, with proper medical guidance. 
  • Adults: Those with a history of angioedema, renal artery stenosis
  • Elderlies: Yes, may require dosage adjustments due to kidney function. 
  • Pregnancy and Lactation: Not recommended, as it may harm the fetus or nursing baby.


People who have had an allergic reaction to any ACE inhibitor should not take Lisinopril. 

Warnings and precautions:

  • Lisinopril can be taken with or without food. 
  • It may cause a dry cough.
  • Monitor blood pressure regularly. 

Drug and Food Interactions 

  • Lisinopril can interact with diuretics, potassium supplements, lithium, and NSAIDs. 
  • Take with caution with food rich in potassium (K) content such as beans, peas, nuts, bananas, avocados and green leafy vegetables    

Side Effects

  • Common side effects include dry cough, dizziness, and headache. 
  • Serious side effects may include high potassium levels, kidney problems, or liver dysfunction. 

Pharmacist Tips

Medication Adherence: 

  • Take Lisinopril at the same time each day to maintain an even level in your bloodstream. 

Blood Pressure Monitoring: 

  • Keep a log of your blood pressure readings to share with your doctor during visits. 

Lifestyle Modifications: 

  • Incorporate diet and exercise recommended for hypertension management alongside medication. 

Potassium Levels: 

  • Monitor potassium intake, as Lisinopril can increase potassium levels in the blood. 

Storage Information: 

  • Store Lisinopril at room temperature, away from excess heat and moisture. 

Handling Instructions: 

  • If you miss a dose, take it as soon as possible. If it's almost time for your next dose, skip the missed dose and continue on your regular schedule. 


Where is Lisinopril available in Hong Kong?

Lisinopril is a prescription medication that can be prescribed by healthcare providers.


Is Lisinopril for purchase over-the-counter? 

No, Lisinopril requires a prescription from a healthcare provider. 

Can I take Lisinopril during pregnancy?

Lisinopril is not recommended during pregnancy due to the risk of harm to the fetus (teratogenic side-effect).

How long does it take for Lisinopril to lower blood pressure?

Lisinopril usually starts to lower blood pressure within hours of the first dose, but the full effect may take a few weeks. 

How long does Lisinopril stay in your system? 

Lisinopril has a half-life of about 12 hours, meaning it takes approximately 60 hours, or 2.5 days, for the drug to be eliminated from your system after the last dose. However, its effects on lowering blood pressure may last longer.
By understanding and properly managing your Lisinopril treatment, you can effectively control your blood pressure or manage heart failure symptoms. Consult your healthcare provider or pharmacist for any additional questions or concerns about this medication. 

This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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