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Difflam is used to treat symptoms of pain and inflammation in the throat and mouth, such as sore throat, mouth ulcers, and dental pain.

Last Modified: 06 May 2024

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What is Difflam? 

Difflam, known for its anti-inflammatory and analgesic properties, is a medication that contains the active ingredient benzydamine hydrochloride. It is part of a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs). 

The drug's structure allows it to be effective in targeting sites of inflammation and pain. Difflam is made through a chemical synthesis process that produces the active compound benzydamine hydrochloride. 

Global Name

Generic name:  Benzydamine
Brand names: Difflam, Tantum Verde, and Benzydamine among others


What is Difflam used for? 

Difflam is used to treat symptoms of pain and inflammation in the throat and mouth, such as sore throat, mouth ulcers, and dental pain. It is also used for the relief of pain and swelling after dental surgery or procedures. 

How do you use Difflam? 


Difflam is available in a variety of forms, including oral rinse, spray, lozenge, cream, and gel. 

Dosage information: 

  • For mouth and throat conditions, use as directed on the product packaging or by your healthcare provider. 
  • Cream and gel forms should be applied topically to the affected area 2-3 times daily. 


  • Children: Certain formulations are suitable for children, but consult a healthcare provider for appropriate dosage. 
  • Adults: Suitable for use in adults. 
  • Elderlies: Suitable for use, with no special dose adjustments typically required. 
  • Pregnancy: Should be used only if clearly needed and directed by a healthcare provider. 
  • Lactation: Consult with a healthcare provider before use during breastfeeding. 


Individuals allergic to benzydamine or any other NSAIDs should not use Difflam. 

Any warnings and precautions : 

  • Avoid contact with eyes and do not apply to open wounds or damaged skin if using the topical form. 

There are few known significant drug interactions with Difflam. However, it is always best to inform your healthcare provider of all medications you are taking. 

Side Effects

Some common side effects include local numbness or stinging sensation in the mouth or throat when using oral forms, and skin irritation when using topical forms. 

Pharmacist Tips

Storage Information: 

  • Store Difflam at room temperature, away from light and moisture. Do not freeze the oral rinse or spray. 

Handling Instructions: 

  • When using Difflam spray or oral rinse, make sure to follow the dosing instructions carefully. For topical forms, clean and dry the affected area before application. 


Where is Difflam available in Hong Kong?

Difflam is an over-the-counter (OTC) medication that can be sold without a prescription. It is found in all chain drug stores, including Mannings and Watsons. 


Can Difflam be used for toothache?

Yes, Difflam can be used to relieve pain from toothaches, particularly when using the oral rinse or spray formulations.

How often can you use Difflam throat spray?

Difflam throat spray can generally be used every 1.5 to 3 hours, but follow the specific instructions on the product label or the advice of your healthcare provider.

Can Difflam be swallowed?

The oral rinse should not be swallowed. It is meant to be gargled or used as a mouthwash and then spat out. Follow the product instructions carefully.

Is Difflam suitable for children?

Certain Difflam products may be suitable for children at specific doses. It is important to check the product label and consult with a healthcare provider regarding the appropriate use for children.

How many times a day can you take Difflam?

The frequency of Difflam use depends on the form of the medication. For oral rinse or spray, it is typically used every 1.5 to 3 hours as needed, not exceeding the maximum daily dose as per the product's instructions. For the cream or gel, it is usually applied 2-3 times daily or as directed by a healthcare provider. Always adhere to the dosing guidelines provided on the packaging or by a healthcare professional. 


This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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