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Celebrex

Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits the COX-2 enzyme, reducing inflammation and pain.

Last Modified: 22 May 2024

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Overview

What is Celebrex? 

Celebrex, known generically as celecoxib, is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits the COX-2 enzyme, reducing inflammation and pain. 

Celecoxib is a sulfonamide-containing anti-inflammatory drug and is chemically synthesized. Its selective action targets cyclooxygenase-2 (COX-2) enzymes, reducing the risk of gastrointestinal irritation compared to non-selective NSAIDs. 

Generic name  

Generic Name

  • The generic name for Celebrex is Celecoxib. 

Brand Names 

  • Cobix - This brand has been available in countries like India. 
  • Celcoxx - This drug can be found in some Asian countries. 
  • Selecap - This brand is available in various international markets. 

Usage

What is Celebrex used for?

Celebrex is used to treat pain and inflammation associated with various conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and short-term pain relief of headaches and muscle pains. 


How do you use Celebrex?

Availability: 

Celebrex is available in capsule form. 

Dosage Information 

  • Osteoarthritis: 200 mg once daily or 100 mg twice daily. 
  • Rheumatoid Arthritis: 100-200 mg twice daily. 
  • Ankylosing Spondylitis: 200 mg once daily, up to 400 mg if needed. 
  • Acute Pain: 400 mg initially, followed by 200 mg if needed on the first day.

Who Can't Take Celebrex

  • Children: Not recommended for children under 2 years or below 10 kg. 
  • Adults: Suitable with proper dosage adjustments. 
  • Elderlies: May require dosage adjustments due to kidney function. 

Is there anyone who can’t take Celebrex? 

  • Children: Not below 2 years or under 10 kg. 
  • Adults: Those with severe heart or liver issues should avoid it. 
  • Elderlies: Use with caution, monitoring kidney function. 
  • Pregnancy and Lactation: Not recommended, especially in the third trimester. 

Any allergies people might have that aren’t suitable to take the drug 

Those with allergies to sulfa drugs, aspirin, or other NSAIDs should not take Celebrex. 

Any warnings and precautions 

Celebrex can increase the risk of heart attack or stroke and should not be taken before or after heart bypass surgery. It's best taken with food to minimize gastrointestinal discomfort. 

Interactions and contraindications of the drug 

Celebrex can interact with other NSAIDs, blood thinners, ACE inhibitors, and diuretics. It's contraindicated in patients with active gastrointestinal bleeding.

Side Effects

Common side effects include stomach pain, diarrhea, and gas. Serious side effects may involve heart or circulation problems. 

Pharmacist Tips

  • Starting Celebrex: Take the lowest dose for the shortest duration to manage symptoms. 
  • Missed Dose: Take the missed dose as soon as you remember. Skip it if it's close to the next scheduled dose. 
  • Alcohol Consumption: Limit alcohol as it can increase the risk of stomach bleeding. 
  • Storage Information: Store at room temperature away from moisture and heat. 
  • Regular Checkups: Monitor blood pressure regularly, as Celebrex can cause an increase. 
  • Adherence to Therapy: Do not discontinue Celebrex abruptly without consulting your healthcare provider. 
  • Diet Considerations: Maintain a balanced diet; stay hydrated to help kidney function. 

For further guidance on Celebrex or if you have concerns, always consult with your healthcare provider. 

Availability

Where is Celebrex available in Hong Kong?

Celebrex is a prescription medication that can be prescribed by healthcare providers.

FAQs

Is Celebrex safer than other NSAIDs?  

Celebrex is a COX-2 selective inhibitor, which may provide a safer profile for patients with gastric hyperacidity or prone to peptic ulcer disease, but risks for heart and kidney issues are still a concern. 

Can I take Celebrex for long-term pain management? 

To monitor for side effects, Celebrex can be used for chronic conditions under medical supervision. 

Is Celebrex available for purchase over the counter?   

No, Celebrex requires a prescription from a healthcare provider.

How long does it take for Celebrex to work?   

For some acute pain conditions, patients may begin to feel relief within a few hours after taking the medication (peak plasma concentration ~ 3 hours after intake). However, for chronic inflammatory conditions like arthritis, it may take a few days to a week to notice a significant reduction in pain and improvement in function. 

Disclaimer
This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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