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Actifed with Codeine Syrup

A cough suppressant and antihistamine combination used to treat cold symptoms.

Last Modified: 21 May 2024

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What is Actifed with Codeine Syrup?

Actifed with Codeine Syrup is a combination medication that is formulated to relieve multiple symptoms associated with the common cold, allergies, and various respiratory conditions. The active ingredients in Actifed with Codeine Syrup typically include triprolidine hydrochloride, pseudoephedrine hydrochloride, and codeine phosphate. Triprolidine is an antihistamine that reduces the effects of the natural chemical histamine in the body, pseudoephedrine is a decongestant, and codeine is an opiate used to suppress coughing. 

Quick Breakdown of Actifed with Codeine's Structure 

  • Triprolidine hydrochloride: an antihistamine that relieves allergy symptoms. 
  • Pseudoephedrine hydrochloride: decongestant that reduces nasal congestion. 
  • Codeine phosphate: narcotic cough suppressant. 

Global Name

Generic name: Triprolidine, Pseudoephedrine, and Codeine Syrup 
Brand names: Actifed with Codeine, Actifed-C Codeine, Tuxarin-ER, among others. 


What is Actifed with Codeine Syrup used for?

Actifed with Codeine Syrup is primarily used to treat symptoms caused by the common cold, allergies, or other breathing illnesses such as: 

  • Nasal congestion 
  • Runny nose 
  • Sneezing 
  • Itchy or watery eyes
  • Coughing due to minor throat and bronchial irritation 

How do you use Actifed with Codeine Syrup?

Dosage Information 

  • Follow the dosage instructions provided by your doctor or on the label. 
  • Dosage may vary based on age and the specific condition being treated. 

Suitability for Different Age Groups and Conditions 

  • Children: Not recommended for children under 12 years of age; physician-directed use only for 12–18-year-olds. 
  • Adults: Suitable when taken as directed. 
  • Elderlies: May require dosage adjustments due to potentially slower metabolism increased sensitivity and possible drug-drug interaction (with maintenance medications). 
  • Pregnancy and Lactation (Breastfeeding/nursing mothers): 
    Pregnancy – generally NOT recommended (due to the opiate component of the drug) 
    Lactationgenerally NOT recommended (due to the opiate component of the drug) 

Who Can't Take Actifed with Codeine Syrup? 

  • Individuals with respiratory depression or obstructive airway disease. 
  • Patients currently or recently using MAO inhibitors. 
  • Anyone with a known hypersensitivity to any of the components. 
  • Children below 12 years old 

Allergies and Precautions 

  • Avoid if allergic to triprolidine, pseudoephedrine, codeine, or related drugs. 
  • Use caution in patients with high blood pressure, heart disease, thyroid disease, diabetes, or difficulty in urination due to an enlarged prostate gland. 

Warnings and Meal Timing 

  • Some versions must be taken with or without food; consult your pharmacist. 
  • It may cause drowsiness; avoid driving or operating heavy machinery. 

Interactions and Contraindications 

  • It can interact with alcohol, MAO inhibitors, sedatives, and muscle relaxants. 
  • Avoid using other products containing decongestants or antihistamines. 

Side Effects

Common side effects may include drowsiness, dizziness, and dry mouth. Severe side effects could be difficulty breathing, fast or irregular heartbeat, severe rash or elevated blood pressure. 

"Actifed with Codeine can cause side effects, please consult your healthcare provider if you experience any unusual symptoms." 

Pharmacist Tips

Storage Information 

  • Store at room temperature, away from light and moisture. 
  • Do not store it in the bathroom. 

Handling Instructions 

  • Shake the bottle well before each use. 
  • Use the measuring device that comes with the product for accurate dosing. 


Where is Actifed with Codeine Syrup available in Hong Kong?

Actifed with Codeine is either Prescription Only (bought with a doctor’s prescription) or Pharmacy Only (can be bought without a doctor’s prescription but in the presence and under the supervision of a registered pharmacist). You cannot buy Actifed with Codeine syrup over the counter. 


Can Actifed with Codeine Syrup make you sleepy? 

Yes, one of the common side effects of Actifed with Codeine Syrup is drowsiness. 

How long can I use Actifed with Codeine Syrup for a cough? 

You should not use Actifed with Codeine Syrup for more than 7 days unless directed by a healthcare provider. 

Can I take Actifed with Codeine Syrup if I have high blood pressure? 

Caution is advised when taking Actifed with Codeine Syrup if you have high blood pressure; consult your healthcare provider. 

This website provides content related to drug use and medicine for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Do not use the information on this website to diagnose or treat a health problem or disease without consulting a qualified healthcare provider. The website's owners and contributors are not liable for any repercussions, adverse effects, or consequences resulting from the use of any medication or information provided herein.

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