Antibodies Post-Vaccination: Can I Test if My Vaccine Has Been Effective?


Normally when giving vaccinations we assume the vaccine to be effective. There are some situations in which we test the presence of immunity. For example, we test people who are considering pregnancy or who are newly pregnant to ensure they are immune to rubella or chickenpox and we test healthcare workers and at-risk individuals to make sure they are immune to Hepatitis B post-vaccination.

It is unclear, as yet, how vaccination status will influence public health controls and restrictions for vaccinated individuals going forwards. The recent proposal to reduce quarantine for arrivals who are shown to have a positive antibody test indicates that the government will be using antibody levels as one of the strategies to mitigate risk. People in Hong Kong who are hospitalised with Covid are kept in hospital until they reach a ‘safe threshold’ for discharge based upon a measure of viral load and positive antibody test. Hong Kong has so far been reluctant to treat vaccinated individuals as if they are immune. It seems that, at least in some circumstances, the backup of a positive antibody test may provide the extra reassurance needed to relax some restrictions

Antibody Testing post-vaccination

There are a number of blood tests which measure antibodies against the SARS-Cov-2 virus. An IGG test becomes positive within the first few weeks of the illness or vaccination. A number of reliable antibody tests are now available. We have an increasingly large dataset around the effectiveness of vaccination and the results are very impressive. At OT&P we are consistently seeing high antibody levels after vaccination. This is especially so for BioNTech vaccination.

Example of post-vaccine immunity. Over 50 is considered immune. Most cases we see are measured in the thousands and it is not uncommon to see cases, as above, beyond the upper measurable limit.

How long will protection last for?

It is too early to say but we are building increasing evidence of immunity 10 months after natural infection even in individuals without an antibody response at that point. This is due to the strong secondary immunity provided by T-cells and memory cells. It would be surprising, in view of the high initial antibody levels, if vaccination does not last for at least one year and quite possibly much longer.

Written by Dr David Owens

Please note that all medical articles featured on our website have been reviewed by qualified healthcare doctors. The articles are for general information only and are not medical opinions nor should the contents be used to replace the need for a personal consultation with a qualified medical professional on the reader's medical condition.

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